POL5551, a novel and potent CXCR4 antagonist, enhances sensitivity to chemotherapy in pediatric ALL

The importance of the cell surface receptor CXCR4 and the chemokine stromal cell-derived factor-1 (SDF-1/CXCL12) is well-established in normal and malignant hematopoiesis. The Protein Epitope Mimetic POL5551 is a novel and potent antagonist of CXCR4. POL5551 efficiently mobilizes hematopoietic stem...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Sison, Edward Allan R., Magoon, Daniel, Li, Li, Annesley, Colleen E., Romagnoli, Barbara, Douglas, Garry J., Tuffin, Gerald, Zimmermann, Johann, Brown, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741576/
https://ncbi.nlm.nih.gov/pubmed/26360610
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