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Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation
Ubiquitylation of histone H2B at lysine 120 (H2B-Ub), a post-translational modification first discovered in 1980, plays a critical role in diverse nuclear processes including the regulation of transcription and DNA damage repair. Herein, we use a suite of protein chemistry methods to explore how H2B...
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| 發表在: | Nat Commun |
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| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4740876/ https://ncbi.nlm.nih.gov/pubmed/26830124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10589 |
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