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RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair
XRCC4-like factor (XLF) functions in classical non-homologous end-joining (cNHEJ) but is dispensable for the repair of DNA double-strand breaks (DSBs) generated during V(D)J recombination. A long-standing hypothesis proposes that, in addition to its canonical nuclease activity, the RAG1/2 proteins p...
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| Veröffentlicht in: | Nat Commun |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4740868/ https://ncbi.nlm.nih.gov/pubmed/26833222 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10529 |
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