Endomucin prevents leukocyte–endothelial cell adhesion and has a critical role under resting and inflammatory conditions

Endomucin is a membrane-bound glycoprotein expressed luminally by endothelial cells that line postcapillary venules, a primary site of leukocyte recruitment during inflammation. Here we show that endomucin abrogation on quiescent endothelial cells enables neutrophils to adhere firmly, via LFA-1-medi...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Zahr, Alisar, Alcaide, Pilar, Yang, Jinling, Jones, Alexander, Gregory, Meredith, dela Paz, Nathaniel G., Patel-Hett, Sunita, Nevers, Tania, Koirala, Adarsha, Luscinskas, Francis W., Saint-Geniez, Magali, Ksander, Bruce, D'Amore, Patricia A., Argüeso, Pablo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740757/
https://ncbi.nlm.nih.gov/pubmed/26831939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10363
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