Inhibition of Cellular Adhesion by Immunological Targeting of Osteopontin Neoepitopes Generated through Matrix Metalloproteinase and Thrombin Cleavage

Osteopontin (OPN), a secreted protein involved in inflammatory processes and cancer, induces cell adhesion, migration, and activation of inflammatory pathways in various cell types. Cells bind OPN via integrins at a canonical RGD region in the full length form as well as to a contiguous cryptic site...

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Publicat a:PLoS One
Autors principals: Jürets, Alexander, Le Bras, Marie, Staffler, Günther, Stein, Gesine, Leitner, Lukas, Neuhofer, Angelika, Tardelli, Matteo, Turkof, Edvin, Zeyda, Maximilian, Stulnig, Thomas M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740464/
https://ncbi.nlm.nih.gov/pubmed/26840958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148333
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