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Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue

INTRODUCTION: Left ventricular dysfunction is a frequent and potentially severe side effect of many tyrosine kinase inhibitors (TKI). The mode of toxicity is not identified, but may include impairment of mitochondrial or sarcomeric function, autophagy or angiogenesis, either as an on-target or off-t...

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הוצא לאור ב:	PLoS One
Main Authors:	Jacob, Fabian, Yonis, Amina Y., Cuello, Friederike, Luther, Pradeep, Schulze, Thomas, Eder, Alexandra, Streichert, Thomas, Mannhardt, Ingra, Hirt, Marc N., Schaaf, Sebastian, Stenzig, Justus, Force, Thomas, Eschenhagen, Thomas, Hansen, Arne
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Public Library of Science 2016
נושאים:	Research Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4740402/ https://ncbi.nlm.nih.gov/pubmed/26840448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145937
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Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue

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