Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue

INTRODUCTION: Left ventricular dysfunction is a frequent and potentially severe side effect of many tyrosine kinase inhibitors (TKI). The mode of toxicity is not identified, but may include impairment of mitochondrial or sarcomeric function, autophagy or angiogenesis, either as an on-target or off-t...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Jacob, Fabian, Yonis, Amina Y., Cuello, Friederike, Luther, Pradeep, Schulze, Thomas, Eder, Alexandra, Streichert, Thomas, Mannhardt, Ingra, Hirt, Marc N., Schaaf, Sebastian, Stenzig, Justus, Force, Thomas, Eschenhagen, Thomas, Hansen, Arne
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740402/
https://ncbi.nlm.nih.gov/pubmed/26840448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145937
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