Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding

Plasmodium falciparum exports proteins into erythrocytes using the Plasmodium export element (PEXEL) motif, which is cleaved in the endoplasmic reticulum (ER) by plasmepsin V (PMV). A recent study reported that phosphatidylinositol-3-phosphate (PI(3)P) concentrated in the ER binds to PEXEL motifs an...

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Publicat a:Nat Commun
Autors principals: Boddey, Justin A., O'Neill, Matthew T., Lopaticki, Sash, Carvalho, Teresa G., Hodder, Anthony N., Nebl, Thomas, Wawra, Stephan, van West, Pieter, Ebrahimzadeh, Zeinab, Richard, Dave, Flemming, Sven, Spielmann, Tobias, Przyborski, Jude, Babon, Jeff J., Cowman, Alan F.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740378/
https://ncbi.nlm.nih.gov/pubmed/26832821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10470
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