Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites

The malaria parasite Plasmodium falciparum exports several hundred proteins into the infected erythrocyte that are involved in cellular remodeling and severe virulence. The export mechanism involves the Plasmodium export element (PEXEL), which is a cleavage site for the parasite protease, Plasmepsin...

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Detalhes bibliográficos
Main Authors: Sleebs, Brad E., Lopaticki, Sash, Marapana, Danushka S., O'Neill, Matthew T., Rajasekaran, Pravin, Gazdik, Michelle, Günther, Svenja, Whitehead, Lachlan W., Lowes, Kym N., Barfod, Lea, Hviid, Lars, Shaw, Philip J., Hodder, Anthony N., Smith, Brian J., Cowman, Alan F., Boddey, Justin A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077696/
https://ncbi.nlm.nih.gov/pubmed/24983235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001897
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