Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites

The malaria parasite Plasmodium falciparum exports several hundred proteins into the infected erythrocyte that are involved in cellular remodeling and severe virulence. The export mechanism involves the Plasmodium export element (PEXEL), which is a cleavage site for the parasite protease, Plasmepsin...

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Autori principali: Sleebs, Brad E., Lopaticki, Sash, Marapana, Danushka S., O'Neill, Matthew T., Rajasekaran, Pravin, Gazdik, Michelle, Günther, Svenja, Whitehead, Lachlan W., Lowes, Kym N., Barfod, Lea, Hviid, Lars, Shaw, Philip J., Hodder, Anthony N., Smith, Brian J., Cowman, Alan F., Boddey, Justin A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077696/
https://ncbi.nlm.nih.gov/pubmed/24983235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001897
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