Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding

Plasmodium falciparum exports proteins into erythrocytes using the Plasmodium export element (PEXEL) motif, which is cleaved in the endoplasmic reticulum (ER) by plasmepsin V (PMV). A recent study reported that phosphatidylinositol-3-phosphate (PI(3)P) concentrated in the ER binds to PEXEL motifs an...

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Publicado no:Nat Commun
Main Authors: Boddey, Justin A., O'Neill, Matthew T., Lopaticki, Sash, Carvalho, Teresa G., Hodder, Anthony N., Nebl, Thomas, Wawra, Stephan, van West, Pieter, Ebrahimzadeh, Zeinab, Richard, Dave, Flemming, Sven, Spielmann, Tobias, Przyborski, Jude, Babon, Jeff J., Cowman, Alan F.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740378/
https://ncbi.nlm.nih.gov/pubmed/26832821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10470
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