Rare, low frequency, and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans

The common nonsynonymous variant rs16969968 in the α5 nicotinic receptor subunit gene (CHRNA5) is the strongest genetic risk factor for nicotine dependence in European Americans and contributes to risk in African Americans. To comprehensively examine whether other CHRNA5 coding variation influences...

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Udgivet i:Mol Psychiatry
Main Authors: Olfson, Emily, Saccone, Nancy L., Johnson, Eric O., Chen, Li-Shiun, Culverhouse, Robert, Doheny, Kimberly, Foltz, Steven M., Fox, Louis, Gogarten, Stephanie M., Hartz, Sarah, Hetrick, Kurt, Laurie, Cathy C., Marosy, Beth, Amin, Najaf, Arnett, Donna, Barr, R. Graham, Bartz, Traci M., Bertelsen, Sarah, Borecki, Ingrid B., Brown, Michael R., Chasman, Daniel I., van Duijn, Cornelia M., Feitosa, Mary F., Fox, Ervin R., Franceschini, Nora, Franco, Oscar H., Grove, Megan L., Guo, Xiuqing, Hofman, Albert, Kardia, Sharon L.R., Morrison, Alanna C., Musani, Solomon K., Psaty, Bruce M., Rao, D.C., Reiner, Alex P., Rice, Kenneth, Ridker, Paul M., Rose, Lynda M., Schick, Ursula M., Schwander, Karen, Uitterlinden, Andre G., Vojinovic, Dina, Wang, Jen-Chyong, Ware, Erin B., Wilson, Gregory, Yao, Jie, Zhao, Wei, Breslau, Naomi, Hatsukami, Dorothy, Stitzel, Jerry A., Rice, John, Goate, Alison, Bierut, Laura J.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740321/
https://ncbi.nlm.nih.gov/pubmed/26239294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2015.105
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