A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence

Nicotine dependence is influenced by chromosome 15q25.1 single nucleotide polymorphisms (SNPs), including the missense SNP rs16969968 that alters function of the α5 nicotinic acetylcholine receptor (CHRNA5) and noncoding SNPs that regulate CHRNA5 mRNA expression. We tested for cis-methylation quanti...

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Veröffentlicht in:Hum Mol Genet
Hauptverfasser: Hancock, Dana B., Wang, Jen-Chyong, Gaddis, Nathan C., Levy, Joshua L., Saccone, Nancy L., Stitzel, Jerry A., Goate, Alison, Bierut, Laura J., Johnson, Eric O.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
Schlagworte:
Association Studies Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4581607/
https://ncbi.nlm.nih.gov/pubmed/26220977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv303
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