A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence

Nicotine dependence is influenced by chromosome 15q25.1 single nucleotide polymorphisms (SNPs), including the missense SNP rs16969968 that alters function of the α5 nicotinic acetylcholine receptor (CHRNA5) and noncoding SNPs that regulate CHRNA5 mRNA expression. We tested for cis-methylation quanti...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Hancock, Dana B., Wang, Jen-Chyong, Gaddis, Nathan C., Levy, Joshua L., Saccone, Nancy L., Stitzel, Jerry A., Goate, Alison, Bierut, Laura J., Johnson, Eric O.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Association Studies Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4581607/
https://ncbi.nlm.nih.gov/pubmed/26220977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv303
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