Linezolid Trough Concentrations Correlate with Mitochondrial Toxicity-Related Adverse Events in the Treatment of Chronic Extensively Drug-Resistant Tuberculosis

Long-term linezolid use is limited by mitochondrial toxicity-associated adverse events (AEs). Within a prospective, randomized controlled trial of linezolid to treat chronic extensively drug-resistant tuberculosis, we serially monitored the translational competence of mitochondria isolated from peri...

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Publicado en:EBioMedicine
Main Authors: Song, Taeksun, Lee, Myungsun, Jeon, Han-Seung, Park, Yumi, Dodd, Lori E., Dartois, Véronique, Follman, Dean, Wang, Jing, Cai, Ying, Goldfeder, Lisa C., Olivier, Kenneth N., Xie, Yingda, Via, Laura E., Cho, Sang Nae, Barry, Clifton E., Chen, Ray Y.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2015
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740314/
https://ncbi.nlm.nih.gov/pubmed/26870788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.09.051
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