Safety and Tolerability of ACP-501, a Recombinant Human Lecithin:Cholesterol Acyltransferase, in a Phase 1 Single-Dose Escalation Study

RATIONALE: Low high-density lipoprotein cholesterol (HDL-C) in coronary heart disease (CHD) patients may be due to rate-limiting amounts of lecithin:cholesterol acyltransferase (LCAT). Raising LCAT may be beneficial for CHD, as well as for Familial LCAT Deficiency (FLD), a rare disorder of low HDL-C...

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Pubblicato in:Circ Res
Autori principali: Shamburek, Robert D., Bakker-Arkema, Rebecca, Shamburek, Alexandra M., Freeman, Lita A., Amar, Marcelo J., Auerbach, Bruce, Krause, Brian R., Homan, Reynold, Adelman, Steve J., Collins, Heidi L., Sampson, Maureen, Wolska, Anna, Remaley, Alan T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740220/
https://ncbi.nlm.nih.gov/pubmed/26628614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.306223
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