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Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts

In human adult erythroid cells, lower than normal levels of Krüppel-like transcription factor 1 (KLF1) are generally associated with decreased adult β- and increased fetal γ-globin gene expression. KLF1 also regulates BCL11A, a known repressor of adult γ-globin expression. In seeming contrast to the...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Vinjamur, Divya S., Alhashem, Yousef N., Mohamad, Safa F., Amin, Parth, Williams, David C., Lloyd, Joyce A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739742/
https://ncbi.nlm.nih.gov/pubmed/26840243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146802
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