Krüppel-Like Factor 1 (KLF1), KLF2, and Myc Control a Regulatory Network Essential for Embryonic Erythropoiesis

The Krüppel-like factor 1 (KLF1) and KLF2 positively regulate embryonic β-globin expression and have additional overlapping roles in embryonic (primitive) erythropoiesis. KLF1(−/−) KLF2(−/−) double knockout mice are anemic at embryonic day 10.5 (E10.5) and die by E11.5, in contrast to single knockou...

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Auteurs principaux: Pang, Christopher J., Lemsaddek, Wafaa, Alhashem, Yousef N., Bondzi, Cornelius, Redmond, Latasha C., Ah-Son, Nicolas, Dumur, Catherine I., Archer, Kellie J., Haar, Jack L., Lloyd, Joyce A., Trudel, Marie
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2012
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434496/
https://ncbi.nlm.nih.gov/pubmed/22566683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00104-12
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