A New Animal Model for Investigation of Mechanical Unloading in Hypertrophic and Failing Hearts: Combination of Transverse Aortic Constriction and Heterotopic Heart Transplantation

OBJECTIVES: Previous small animal models for simulation of mechanical unloading are solely performed in healthy or infarcted hearts, not representing the pathophysiology of hypertrophic and dilated hearts emerging in heart failure patients. In this article, we present a new and economic small animal...

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Veröffentlicht in:PLoS One
Hauptverfasser: Schaefer, Andreas, Schneeberger, Yvonne, Stenzig, Justus, Biermann, Daniel, Jelinek, Marisa, Reichenspurner, Hermann, Eschenhagen, Thomas, Ehmke, Heimo, Schwoerer, Alexander P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739720/
https://ncbi.nlm.nih.gov/pubmed/26841021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148259
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