A New Animal Model for Investigation of Mechanical Unloading in Hypertrophic and Failing Hearts: Combination of Transverse Aortic Constriction and Heterotopic Heart Transplantation

OBJECTIVES: Previous small animal models for simulation of mechanical unloading are solely performed in healthy or infarcted hearts, not representing the pathophysiology of hypertrophic and dilated hearts emerging in heart failure patients. In this article, we present a new and economic small animal...

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Publicado en:PLoS One
Autores principales: Schaefer, Andreas, Schneeberger, Yvonne, Stenzig, Justus, Biermann, Daniel, Jelinek, Marisa, Reichenspurner, Hermann, Eschenhagen, Thomas, Ehmke, Heimo, Schwoerer, Alexander P.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739720/
https://ncbi.nlm.nih.gov/pubmed/26841021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148259
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