A New Animal Model for Investigation of Mechanical Unloading in Hypertrophic and Failing Hearts: Combination of Transverse Aortic Constriction and Heterotopic Heart Transplantation

OBJECTIVES: Previous small animal models for simulation of mechanical unloading are solely performed in healthy or infarcted hearts, not representing the pathophysiology of hypertrophic and dilated hearts emerging in heart failure patients. In this article, we present a new and economic small animal...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Schaefer, Andreas, Schneeberger, Yvonne, Stenzig, Justus, Biermann, Daniel, Jelinek, Marisa, Reichenspurner, Hermann, Eschenhagen, Thomas, Ehmke, Heimo, Schwoerer, Alexander P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739720/
https://ncbi.nlm.nih.gov/pubmed/26841021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148259
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