The heterotopic heart transplantation in mice as a small animal model to study mechanical unloading – Establishment of the procedure, perioperative management and postoperative scoring

BACKGROUND: Unloading of failing hearts by left ventricular assist devices induces an extensive cardiac remodeling which may lead to a reversal of the initial phenotype–or to its deterioration. The mechanisms underlying these processes are unclear. HYPOTHESIS: Heterotopic heart transplantion (hHTX)...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Westhofen, Sumi, Jelinek, Marisa, Dreher, Leonie, Biermann, Daniel, Martin, Jack, Vitzhum, Helga, Reichenspurner, Hermann, Ehmke, Heimo, Schwoerer, Alexander Peter
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2019
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461225/
https://ncbi.nlm.nih.gov/pubmed/30978185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0214513
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