Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis

[Image: see text] Steadily increasing antifungal drug resistance and persistent high rates of fungal-associated mortality highlight the dire need for the development of novel antifungals. Characterization of inhibitors of one enzyme in the GPI anchor pathway, Gwt1, has generated interest in the expl...

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Detalhes bibliográficos
Publicado no:ACS Infect Dis
Main Authors: Mann, Paul A., McLellan, Catherine A., Koseoglu, Sandra, Si, Qian, Kuzmin, Elena, Flattery, Amy, Harris, Guy, Sher, Xinwei, Murgolo, Nicholas, Wang, Hao, Devito, Kristine, de Pedro, Nuria, Genilloud, Olga, Kahn, Jennifer Nielsen, Jiang, Bo, Costanzo, Michael, Boone, Charlie, Garlisi, Charles G., Lindquist, Susan, Roemer, Terry
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739577/
https://ncbi.nlm.nih.gov/pubmed/26878058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/id5000212
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