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Minimizing fucosylation in insect cell-derived glycoproteins reduces binding to IgE antibodies from the sera of patients with allergy

The baculovirus/insect cell system has proven to be a very powerful tool for the expression of several therapeutics. Nevertheless, these products sometimes suffer from reduced biological activity and unwanted side effects. Several studies have demonstrated that glycosylation can greatly influence th...

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Dades bibliogràfiques
Publicat a:Biotechnol J
Autors principals: Palmberger, Dieter, Ashjaei, Kazem, Strell, Stephanie, Hoffmann-Sommergruber, Karin, Grabherr, Reingard
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739504/
https://ncbi.nlm.nih.gov/pubmed/24753388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/biot.201400061
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