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Minimizing fucosylation in insect cell-derived glycoproteins reduces binding to IgE antibodies from the sera of patients with allergy

The baculovirus/insect cell system has proven to be a very powerful tool for the expression of several therapeutics. Nevertheless, these products sometimes suffer from reduced biological activity and unwanted side effects. Several studies have demonstrated that glycosylation can greatly influence th...

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Detalhes bibliográficos
Publicado no:Biotechnol J
Main Authors: Palmberger, Dieter, Ashjaei, Kazem, Strell, Stephanie, Hoffmann-Sommergruber, Karin, Grabherr, Reingard
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739504/
https://ncbi.nlm.nih.gov/pubmed/24753388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/biot.201400061
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