Substrate-assisted catalysis in the cleavage of DNA by the EcoRI and EcoRV restriction enzymes.
The crystal structure analyses of the EcoRI-DNA and EcoRV-DNA complexes do not provide clear suggestions as to which amino acid residues are responsible for the activation of water to carry out the DNA cleavage. Based on molecular modeling, we have proposed recently that the attacking water molecule...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1993
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47384/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8378323/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.18.8499 |
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