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Substrate-assisted catalysis in the cleavage of DNA by the EcoRI and EcoRV restriction enzymes.

The crystal structure analyses of the EcoRI-DNA and EcoRV-DNA complexes do not provide clear suggestions as to which amino acid residues are responsible for the activation of water to carry out the DNA cleavage. Based on molecular modeling, we have proposed recently that the attacking water molecule...

詳細記述

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書誌詳細
主要な著者: Jeltsch, A, Alves, J, Wolfes, H, Maass, G, Pingoud, A
フォーマット: Artigo
言語:Inglês
出版事項: 1993
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC47384/
https://ncbi.nlm.nih.gov/pubmed/8378323
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