UHRF1 regulation of the Keap1–Nrf2 pathway in pancreatic cancer contributes to oncogenesis

The cellular defence protein Nrf2 is a mediator of oncogenesis in pancreatic ductal adenocarcinoma (PDAC) and other cancers. However, the control of Nrf2 expression and activity in cancer is not fully understood. We previously reported the absence of Keap1, a pivotal regulator of Nrf2, in ∼70% of PD...

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Detalhes bibliográficos
Publicado no:J Pathol
Main Authors: Abu‐Alainin, Wafa, Gana, Thompson, Liloglou, Triantafillos, Olayanju, Adedamola, Barrera, Lawrence N, Ferguson, Robert, Campbell, Fiona, Andrews, Timothy, Goldring, Christopher, Kitteringham, Neil, Park, Brian K, Nedjadi, Taoufik, Schmid, Michael C, Slupsky, Joseph R, Greenhalf, William, Neoptolemos, John P, Costello, Eithne
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738372/
https://ncbi.nlm.nih.gov/pubmed/26497117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4665
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