Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

BACKGROUND: Nrf2 is a key transcriptional regulator of a battery of genes that facilitate phase II/III drug metabolism and defence against oxidative stress. Nrf2 is largely regulated by Keap1, which directs Nrf2 for proteasomal degradation. The Nrf2/Keap1 system is dysregulated in lung, head and nec...

Full description

Saved in:

Bibliographic Details
Main Authors:	Lister, Adam, Nedjadi, Taoufik, Kitteringham, Neil R, Campbell, Fiona, Costello, Eithne, Lloyd, Bryony, Copple, Ian M, Williams, Samantha, Owen, Andrew, Neoptolemos, John P, Goldring, Chris E, Park, B Kevin
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2011
Subjects:	Research
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3098205/ https://ncbi.nlm.nih.gov/pubmed/21489257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-37
Tags:	Add Tag No Tags, Be the first to tag this record!

Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

Similar Items