Transthyretin participates in beta-amyloid transport from the brain to the liver- involvement of the low-density lipoprotein receptor-related protein 1?

Transthyretin (TTR) binds Aβ peptide, preventing its deposition and toxicity. TTR is decreased in Alzheimer’s disease (AD) patients. Additionally, AD transgenic mice with only one copy of the TTR gene show increased brain and plasma Aβ levels when compared to AD mice with both copies of the gene, su...

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Vydáno v:Sci Rep
Hlavní autoři: Alemi, Mobina, Gaiteiro, Cristiana, Ribeiro, Carlos Alexandre, Santos, Luís Miguel, Gomes, João Rodrigues, Oliveira, Sandra Marisa, Couraud, Pierre-Olivier, Weksler, Babette, Romero, Ignacio, Saraiva, Maria João, Cardoso, Isabel
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738280/
https://ncbi.nlm.nih.gov/pubmed/26837706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20164
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