Imetelstat (a telomerase antagonist) exerts off-target effects on the cytoskeleton

Telomerase is a cellular ribonucleoprotein reverse transcriptase that plays a crucial role in telomere maintenance. This enzyme is expressed in approximately 90% of human tumors, but not in the majority of normal somatic cells. Imetelstat sodium (GRN163L), is a 13-mer oligonucleotide N3′→P5′ thio-ph...

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Detalhes bibliográficos
Publicado no:Int J Oncol
Main Authors: MENDER, ILGEN, SENTURK, SERIF, OZGUNES, NURIMAN, AKCALI, K. CAN, KLETSAS, DIMITRIS, GRYAZNOV, SERGEI, CAN, ALP, SHAY, JERRY W., DIKMEN, Z. GUNNUR
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738197/
https://ncbi.nlm.nih.gov/pubmed/23545855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2013.1865
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