Modulation of EZH2 expression by MEK-ERK or PI3K-AKT signaling in lung cancer is dictated by different KRAS oncogene mutations

EZH2 overexpression promotes cancer by increasing histone methylation to silence tumor suppressor genes, but how EZH2 levels become elevated in cancer is not understood. In this study, we investigated the mechanisms by which EZH2 expression is regulated in non-small cell lung carcinoma cells by onco...

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Vydáno v:Cancer Res
Hlavní autoři: Riquelme, Erick, Behrens, Carmen, Lin, Heather Y., Simon, George, Papadimitrakopoulou, Vassiliki, Izzo, Julie, Moran, Cesar, Kalhor, Neda, Lee, J. Jack, Minna, John D., Wistuba, Ignacio I.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738155/
https://ncbi.nlm.nih.gov/pubmed/26676756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1141
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