Exon-4 Mutations in KRAS Affect MEK/ERK and PI3K/AKT Signaling in Human Multiple Myeloma Cell Lines

Approximately 20% of multiple myeloma (MM) cases harbor a point mutation in KRAS. However, there is still no final consent on whether KRAS-mutations are associated with disease outcome. Specifically, no data exist on whether KRAS-mutations have an impact on survival of MM patients at diagnosis in th...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Weißbach, Susann, Heredia-Guerrero, Sofia Catalina, Barnsteiner, Stefanie, Großhans, Lukas, Bodem, Jochen, Starz, Hanna, Langer, Christian, Appenzeller, Silke, Knop, Stefan, Steinbrunn, Torsten, Rost, Simone, Einsele, Hermann, Bargou, Ralf Christian, Rosenwald, Andreas, Stühmer, Thorsten, Leich, Ellen
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072554/
https://ncbi.nlm.nih.gov/pubmed/32079091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12020455
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