Balancing protein stability and activity in cancer: a new approach for identifying driver mutations affecting CBL ubiquitin ligase activation

Oncogenic mutations in the monomeric Casitas B-lineage lymphoma (Cbl) gene have been found in many tumors, but their significance remains largely unknown. Several human c-Cbl (CBL) structures have recently been solved depicting the protein at different stages of its activation cycle and thus provide...

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Bibliographic Details
Published in:Cancer Res
Main Authors: Li, Minghui, Kales, Stephen C., Ma, Ke, Shoemaker, Benjamin A., Crespo-Barreto, Juan, Cangelosi, Andrew L., Lipkowitz, Stanley, Panchenko, Anna R.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738050/
https://ncbi.nlm.nih.gov/pubmed/26676746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-3812
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