Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury

The mechanism and long-term consequences of early blood–brain barrier (BBB) disruption after cerebral ischaemic/reperfusion (I/R) injury are poorly understood. Here we discover that I/R induces subtle BBB leakage within 30–60 min, likely independent of gelatinase B/MMP-9 activities. The early BBB di...

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保存先:
書誌詳細
出版年:Nat Commun
主要な著者: Shi, Yejie, Zhang, Lili, Pu, Hongjian, Mao, Leilei, Hu, Xiaoming, Jiang, Xiaoyan, Xu, Na, Stetler, R. Anne, Zhang, Feng, Liu, Xiangrong, Leak, Rehana K., Keep, Richard F., Ji, Xunming, Chen, Jun
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2016
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737895/
https://ncbi.nlm.nih.gov/pubmed/26813496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10523
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