Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury

The mechanism and long-term consequences of early blood–brain barrier (BBB) disruption after cerebral ischaemic/reperfusion (I/R) injury are poorly understood. Here we discover that I/R induces subtle BBB leakage within 30–60 min, likely independent of gelatinase B/MMP-9 activities. The early BBB di...

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I publikationen:Nat Commun
Huvudupphovsmän: Shi, Yejie, Zhang, Lili, Pu, Hongjian, Mao, Leilei, Hu, Xiaoming, Jiang, Xiaoyan, Xu, Na, Stetler, R. Anne, Zhang, Feng, Liu, Xiangrong, Leak, Rehana K., Keep, Richard F., Ji, Xunming, Chen, Jun
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737895/
https://ncbi.nlm.nih.gov/pubmed/26813496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10523
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