F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling

During immune surveillance and inflammation, leukocytes exit the vasculature through transient openings in the endothelium without causing plasma leakage. However, the exact mechanisms behind this intriguing phenomenon are still unknown. Here we report that maintenance of endothelial barrier integri...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Heemskerk, Niels, Schimmel, Lilian, Oort, Chantal, van Rijssel, Jos, Yin, Taofei, Ma, Bin, van Unen, Jakobus, Pitter, Bettina, Huveneers, Stephan, Goedhart, Joachim, Wu, Yi, Montanez, Eloi, Woodfin, Abigail, van Buul, Jaap D.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737874/
https://ncbi.nlm.nih.gov/pubmed/26814335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10493
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