Nucleophosmin Mutants Promote Adhesion, Migration and Invasion of Human Leukemia THP-1 Cells through MMPs Up-regulation via Ras/ERK MAPK Signaling

Acute myeloid leukemia (AML) with mutated nucleophosmin (NPM1) has been defined as a unique subgroup in the new classification of myeloid neoplasm, and the AML patients with mutated NPM1 frequently present extramedullary infiltration, but how NPM1 mutants regulate this process remains elusive. In th...

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Bibliographische Detailangaben
Veröffentlicht in:Int J Biol Sci
Hauptverfasser: Xian, Jingrong, Shao, Huiyuan, Chen, Xianchun, Zhang, Shuaishuai, Quan, Jing, Zou, Qin, Jin, Hongjun, Zhang, Ling
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737672/
https://ncbi.nlm.nih.gov/pubmed/26884713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.13382
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