Nucleophosmin Mutants Promote Adhesion, Migration and Invasion of Human Leukemia THP-1 Cells through MMPs Up-regulation via Ras/ERK MAPK Signaling

Acute myeloid leukemia (AML) with mutated nucleophosmin (NPM1) has been defined as a unique subgroup in the new classification of myeloid neoplasm, and the AML patients with mutated NPM1 frequently present extramedullary infiltration, but how NPM1 mutants regulate this process remains elusive. In th...

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Foilsithe in:Int J Biol Sci
Main Authors: Xian, Jingrong, Shao, Huiyuan, Chen, Xianchun, Zhang, Shuaishuai, Quan, Jing, Zou, Qin, Jin, Hongjun, Zhang, Ling
Formáid: Artigo
Teanga:Inglês
Foilsithe: Ivyspring International Publisher 2016
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737672/
https://ncbi.nlm.nih.gov/pubmed/26884713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.13382
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