Elevated O‐GlcNAc Levels Activate Epigenetically Repressed Genes and Delay Mouse ESC Differentiation Without Affecting Naïve to Primed Cell Transition

The differentiation of mouse embryonic stem cells (ESCs) is controlled by the interaction of multiple signaling pathways, typically mediated by post‐translational protein modifications. The addition of O‐linked N‐acetylglucosamine (O‐GlcNAc) to serine and threonine residues of nuclear and cytoplasmi...

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Bibliografiska uppgifter
I publikationen:Stem Cells
Huvudupphovsmän: Speakman, Christopher M., Domke, Tanja C.E., Wongpaiboonwattana, Wikrom, Sanders, Kelly, Mudaliar, Manikhandan, van Aalten, Daan M.F., Barton, Geoffrey J., Stavridis, Marios P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2014
Ämnen:
Embryonic Stem Cells/Induced Pluripotent Stem Cells
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737245/
https://ncbi.nlm.nih.gov/pubmed/24898611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1761
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