Elevated O‐GlcNAc Levels Activate Epigenetically Repressed Genes and Delay Mouse ESC Differentiation Without Affecting Naïve to Primed Cell Transition

The differentiation of mouse embryonic stem cells (ESCs) is controlled by the interaction of multiple signaling pathways, typically mediated by post‐translational protein modifications. The addition of O‐linked N‐acetylglucosamine (O‐GlcNAc) to serine and threonine residues of nuclear and cytoplasmi...

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Bibliografiset tiedot
Julkaisussa:Stem Cells
Päätekijät: Speakman, Christopher M., Domke, Tanja C.E., Wongpaiboonwattana, Wikrom, Sanders, Kelly, Mudaliar, Manikhandan, van Aalten, Daan M.F., Barton, Geoffrey J., Stavridis, Marios P.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2014
Aiheet:
Embryonic Stem Cells/Induced Pluripotent Stem Cells
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737245/
https://ncbi.nlm.nih.gov/pubmed/24898611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1761
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