Elevated O‐GlcNAc Levels Activate Epigenetically Repressed Genes and Delay Mouse ESC Differentiation Without Affecting Naïve to Primed Cell Transition

The differentiation of mouse embryonic stem cells (ESCs) is controlled by the interaction of multiple signaling pathways, typically mediated by post‐translational protein modifications. The addition of O‐linked N‐acetylglucosamine (O‐GlcNAc) to serine and threonine residues of nuclear and cytoplasmi...

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Bibliographic Details
Published in:Stem Cells
Main Authors: Speakman, Christopher M., Domke, Tanja C.E., Wongpaiboonwattana, Wikrom, Sanders, Kelly, Mudaliar, Manikhandan, van Aalten, Daan M.F., Barton, Geoffrey J., Stavridis, Marios P.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2014
Subjects:
Embryonic Stem Cells/Induced Pluripotent Stem Cells
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737245/
https://ncbi.nlm.nih.gov/pubmed/24898611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1761
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