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Periodic-shRNA molecules are capable of gene silencing, cytotoxicity and innate immune activation in cancer cells
Large dsRNA molecules can cause potent cytotoxic and immunostimulatory effects through the activation of pattern recognition receptors; however, synthetic versions of these molecules are mostly limited to simple sequences like poly-I:C and poly-A:U. Here we show that large RNA molecules generated by...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4737167/ https://ncbi.nlm.nih.gov/pubmed/26704983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1488 |
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