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Thiopurine dose intensity and treatment outcome in childhood lymphoblastic leukaemia: the influence of thiopurine methyltransferase pharmacogenetics

The impact of thiopurine methyltransferase (TPMT) genotype on thiopurine dose intensity, myelosuppression and treatment outcome was investigated in the United Kingdom childhood acute lymphoblastic leukaemia (ALL) trial ALL97. TPMT heterozygotes had significantly more frequent cytopenias and therefor...

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Bibliografiske detaljer
Udgivet i:Br J Haematol
Main Authors: Lennard, Lynne, Cartwright, Cher S., Wade, Rachel, Vora, Ajay
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737107/
https://ncbi.nlm.nih.gov/pubmed/25441457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.13240
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