Thiopurine methyltransferase genotype–phenotype discordance and thiopurine active metabolite formation in childhood acute lymphoblastic leukaemia

AIMS: In children with acute lymphoblastic leukaemia (ALL) bone marrow activity can influence red blood cell (RBC) kinetics, the surrogate tissue for thiopurine methyltransferase (TPMT) measurements. The aim of this study was to investigate TPMT phenotype–genotype concordance in ALL, and the influen...

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Autores principales: Lennard, Lynne, Cartwright, Cher Suzanne, Wade, Rachel, Richards, Susan M, Vora, Ajay
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2013
Materias:
Pharmacogenetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703235/
https://ncbi.nlm.nih.gov/pubmed/23252716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12066
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