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Thiopurine dose intensity and treatment outcome in childhood lymphoblastic leukaemia: the influence of thiopurine methyltransferase pharmacogenetics

The impact of thiopurine methyltransferase (TPMT) genotype on thiopurine dose intensity, myelosuppression and treatment outcome was investigated in the United Kingdom childhood acute lymphoblastic leukaemia (ALL) trial ALL97. TPMT heterozygotes had significantly more frequent cytopenias and therefor...

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Publicado en:Br J Haematol
Main Authors: Lennard, Lynne, Cartwright, Cher S., Wade, Rachel, Vora, Ajay
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737107/
https://ncbi.nlm.nih.gov/pubmed/25441457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.13240
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