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Thiopurine dose intensity and treatment outcome in childhood lymphoblastic leukaemia: the influence of thiopurine methyltransferase pharmacogenetics

The impact of thiopurine methyltransferase (TPMT) genotype on thiopurine dose intensity, myelosuppression and treatment outcome was investigated in the United Kingdom childhood acute lymphoblastic leukaemia (ALL) trial ALL97. TPMT heterozygotes had significantly more frequent cytopenias and therefor...

詳細記述

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書誌詳細
出版年:Br J Haematol
主要な著者: Lennard, Lynne, Cartwright, Cher S., Wade, Rachel, Vora, Ajay
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737107/
https://ncbi.nlm.nih.gov/pubmed/25441457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.13240
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