Crystal structure of human immunodeficiency virus (HIV) type 2 protease in complex with a reduced amide inhibitor and comparison with HIV-1 protease structures.

The crystal structure of HIV-2 protease in complex with a reduced amide inhibitor [BI-LA-398; Phe-Val-Phe-psi (CH2NH)-Leu-Glu-Ile-amide] has been determined at 2.2-A resolution and refined to a crystallographic R factor of 17.6%. The rms deviation from ideality in bond lengths is 0.018 A and in bond...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Tong, L, Pav, S, Pargellis, C, Dô, F, Lamarre, D, Anderson, P C
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 1993
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47361/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8378311/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.18.8387
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