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Targeting the PI3K signaling pathway in KRAS mutant colon cancer
Metastatic colorectal cancer (CRC) patients with v‐Ki‐ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations are resistant to monoclonal antibody that targets the epidermal growth factor receptor such as cetuximab. BKM120 targets phosphatidylinositide‐3‐kinase (PIK3CA), but it is unknown w...
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| Publicado no: | Cancer Med |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4735771/ https://ncbi.nlm.nih.gov/pubmed/26715098 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.591 |
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