IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid

Macrophages can be niches for bacterial pathogens or antibacterial effector cells depending on the pathogen and signals from the immune system. Here we show that type I and II IFNs are master regulators of gene expression during Legionella pneumophila infection, and activators of an alveolar macroph...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Naujoks, Jan, Tabeling, Christoph, Dill, Brian D., Hoffmann, Christine, Brown, Andrew S., Kunze, Mareike, Kempa, Stefan, Peter, Andrea, Mollenkopf, Hans-Joachim, Dorhoi, Anca, Kershaw, Olivia, Gruber, Achim D., Sander, Leif E., Witzenrath, Martin, Herold, Susanne, Nerlich, Andreas, Hocke, Andreas C., van Driel, Ian, Suttorp, Norbert, Bedoui, Sammy, Hilbi, Hubert, Trost, Matthias, Opitz, Bastian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4734697/
https://ncbi.nlm.nih.gov/pubmed/26829557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005408
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