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Hypocretin receptor 1 blockade preferentially reduces high effort responding for cocaine without promoting sleep

Recent evidence suggests that blockade of the hypocretin receptor 1 may act as a useful pharmacotherapy for cocaine abuse. Here we investigated the extent to which various doses of a hypocretin receptor 1 antagonist, SB-334867, affect cocaine self-administration at varying doses of cocaine and acros...

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Publicat a:Behav Brain Res
Autors principals: Brodnik, Zachary D., Bernstein, David L., Prince, Courtney D., España, Rodrigo A.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4734652/
https://ncbi.nlm.nih.gov/pubmed/26049058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbr.2015.05.051
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