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Hypocretin / Orexin knock-out mice display disrupted behavioral and dopamine responses to cocaine

The hypocretin/orexin (HCRT) system is implicated in reward and reinforcement processes through actions on the mesolimbic dopamine (DA) system. Here we provide evidence for the relationship between HCRT and DA in vivo in anesthetized and freely-moving mice. The ability of cocaine to elicit reward-re...

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Publicado en:Addict Biol
Main Authors: Shaw, Jessica K., Ferris, Mark J., Locke, Jason L., Brodnik, Zachary D., Jones, Sara R., España, Rodrigo A.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468487/
https://ncbi.nlm.nih.gov/pubmed/27480648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/adb.12432
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