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Proton-gated Ca(2+)-permeable TRP channels damage myelin in conditions mimicking ischaemia
The myelin sheaths wrapped around axons by oligodendrocytes are crucial for brain function. In ischaemia myelin is damaged in a Ca(2+)-dependent manner, abolishing action potential propagation(1,2). This has been attributed to glutamate release activating Ca(2+)-permeable NMDA receptors(2-4). Surpri...
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| Published in: | Nature |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4733665/ https://ncbi.nlm.nih.gov/pubmed/26760212 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature16519 |
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