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Proton-gated Ca(2+)-permeable TRP channels damage myelin in conditions mimicking ischaemia
The myelin sheaths wrapped around axons by oligodendrocytes are crucial for brain function. In ischaemia myelin is damaged in a Ca(2+)-dependent manner, abolishing action potential propagation(1,2). This has been attributed to glutamate release activating Ca(2+)-permeable NMDA receptors(2-4). Surpri...
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| 出版年: | Nature |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4733665/ https://ncbi.nlm.nih.gov/pubmed/26760212 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature16519 |
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